SOX3

Entrez Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked cognitive disability with growth hormone deficiency. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). {ECO:0000250, ECO:0000269|PubMed:21183788}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Screen	Score
R-DABN 8μM R03 exp111	-1.8
Bafilomycin-A1 0.009μM R08 exp454	1.73

HMG box
SOXp

hypothalamus development
sex determination
nuclear transcription factor complex
RNA polymerase II core promoter sequence-specific DNA binding
pituitary gland development
face development
diencephalon development
limbic system development
endocrine system development
negative regulation of neuron differentiation
transcription corepressor activity
negative regulation of neurogenesis
negative regulation of nervous system development
negative regulation of cell development
forebrain development
gland development
sensory organ development
regulation of neuron differentiation
developmental process involved in reproduction
negative regulation of cell differentiation
brain development
head development
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
central nervous system development
neuron differentiation
negative regulation of multicellular organismal process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
reproductive process
reproduction
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
generation of neurons
negative regulation of biosynthetic process