SPESP1

Entrez Summary: N/A
UniProt Summary: Involved in fertilization ability of sperm. {ECO:0000250|UniProtKB:Q9D5A0}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nocodazole 0.2μM R00 exp24	-1.84
Hydroxyurea 100μM R07 exp329	-1.83

fusion of sperm to egg plasma membrane involved in single fertilization
plasma membrane fusion
acrosome reaction
sperm-egg recognition
cell-cell recognition
acrosomal vesicle
membrane fusion
single fertilization
fertilization
cell recognition
cellular process involved in reproduction in multicellular organism
sexual reproduction
multicellular organism reproduction
membrane organization
multi-organism reproductive process
reproductive process
reproduction