STAC

Gene Information

Official Symbol: STAC
Official Name: SH3 and cysteine rich domain
Aliases and Previous Symbols: N/A
Entrez ID: 6769
UniProt: Q99469
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. {ECO:0000250|UniProtKB:P97306}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4649
Expression level (log2 read counts): -6.6

Expression Distribution

Screen	Score
Nocodazole 0.2μM R00 exp24	-1.71
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.8
WYE-354 6μM R02 exp90	1.88

C1 1
SH3 1
SH3 2

positive regulation of voltage-gated calcium channel activity
skeletal muscle contraction
regulation of voltage-gated calcium channel activity
positive regulation of calcium ion transmembrane transporter activity
T-tubule
multicellular organismal movement
musculoskeletal movement
positive regulation of protein localization to plasma membrane
extrinsic component of cytoplasmic side of plasma membrane
positive regulation of protein localization to cell periphery
positive regulation of cation channel activity
positive regulation of calcium ion transmembrane transport
cellular response to heat
regulation of calcium ion transmembrane transporter activity
regulation of protein localization to plasma membrane
positive regulation of ion transmembrane transporter activity
striated muscle contraction
response to heat
positive regulation of transporter activity
regulation of protein localization to cell periphery
positive regulation of calcium ion transport
positive regulation of protein localization to membrane
ion channel binding
positive regulation of cation transmembrane transport
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
regulation of cation channel activity
response to temperature stimulus
regulation of protein localization to membrane
positive regulation of transmembrane transport
regulation of calcium ion transport
muscle contraction
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity
muscle system process
positive regulation of cellular protein localization
regulation of cation transmembrane transport
regulation of metal ion transport