STXBP4

Entrez Summary: N/A
UniProt Summary: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PDZ
WW

positive regulation of keratinocyte proliferation
regulation of keratinocyte proliferation
positive regulation of cell cycle G1/S phase transition
syntaxin binding
regulation of insulin secretion involved in cellular response to glucose stimulus
phagocytic vesicle
regulation of glucose transmembrane transport
insulin receptor signaling pathway
positive regulation of cell cycle phase transition
cellular response to interferon-gamma
cellular response to insulin stimulus
regulation of cell cycle G1/S phase transition
regulation of insulin secretion
protein stabilization
response to interferon-gamma
positive regulation of epithelial cell proliferation
regulation of peptide hormone secretion
response to insulin
cellular response to peptide hormone stimulus
regulation of hormone secretion
positive regulation of cell cycle process
regulation of protein stability
cellular response to peptide
regulation of epithelial cell proliferation
protein targeting
positive regulation of cell cycle
response to peptide hormone
regulation of cell cycle phase transition
regulation of protein secretion
response to peptide
regulation of peptide secretion
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of hormone levels
regulation of transmembrane transport
cellular response to organonitrogen compound
cellular response to hormone stimulus
cellular response to nitrogen compound
regulation of protein transport
enzyme linked receptor protein signaling pathway
regulation of peptide transport