SULT1C4

Entrez Summary: N/A
UniProt Summary: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). {ECO:0000269|PubMed:17425406}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

aryl sulfotransferase activity
ethanol catabolic process
primary alcohol catabolic process
sulfation
ethanol metabolic process
3-phosphoadenosine 5-phosphosulfate metabolic process
purine ribonucleoside bisphosphate metabolic process
sulfotransferase activity
antibiotic catabolic process
alcohol catabolic process
organic hydroxy compound catabolic process
primary alcohol metabolic process
antibiotic metabolic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
drug catabolic process
purine ribonucleotide metabolic process
alcohol metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
sulfur compound metabolic process
purine-containing compound metabolic process
small molecule catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic hydroxy compound metabolic process
drug metabolic process
nucleobase-containing small molecule metabolic process
organophosphate metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process