SYT8

Entrez Summary: N/A
UniProt Summary: Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aminopterin 0.005μM R07 exp335	-2.06
Adefovir 20μM R07 exp332	-1.96
MS094 2μM R03 exp136	-1.94
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-1.93
Genistein 15μM R07 exp360	-1.86
ABT-702 5μM plus CoCl2 18μM R07 exp320	-1.85
Chlorpromazine 10μM R07 exp344	-1.82
CVT-10216 0.1μM R06 exp278	-1.76
YM155 0.0002μM R01 exp61	1.7
Lapatinib 5μM R01 exp47	1.73
IWR1 50μM R08 exp495	1.89

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dense core granule
calcium ion-regulated exocytosis of neurotransmitter
acrosome reaction
exocytic vesicle
clathrin binding
regulation of dopamine secretion
calcium-ion regulated exocytosis
regulation of calcium ion-dependent exocytosis
synaptic vesicle endocytosis
presynaptic endocytosis
synaptic vesicle recycling
syntaxin binding
calcium-dependent phospholipid binding
phosphatidylserine binding
calcium-dependent protein binding
regulation of catecholamine secretion
synaptic vesicle exocytosis
SNARE binding
synaptic vesicle membrane
cellular response to calcium ion
acrosomal vesicle
regulation of amine transport
regulation of response to drug
neurotransmitter secretion
signal release from synapse
synaptic vesicle cycle
vesicle-mediated transport in synapse
single fertilization
response to calcium ion
regulation of regulated secretory pathway
signal release
fertilization
neurotransmitter transport
cellular response to metal ion
cellular response to inorganic substance
regulation of exocytosis
axon
regulation of neurotransmitter levels
response to metal ion
chemical synaptic transmission