TBX20
Gene Information
- Official Symbol: TBX20
- Official Name: T-box transcription factor 20
- Aliases and Previous Symbols: N/A
- Entrez ID: 57057
- UniProt: Q9UMR3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
- UniProt Summary: Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| T-box |
GO Terms
| pulmonary vein morphogenesis |
| embryonic heart tube elongation |
| lateral mesoderm morphogenesis |
| foramen ovale closure |
| lateral mesoderm formation |
| pulmonary valve formation |
| visceral motor neuron differentiation |
| negative regulation of SMAD protein complex assembly |
| regulation of SMAD protein complex assembly |
| tricuspid valve development |
| venous blood vessel morphogenesis |
| pericardium morphogenesis |
| cardiac chamber formation |
| lateral mesoderm development |
| heart valve formation |
| venous blood vessel development |
| atrial septum morphogenesis |
| pulmonary valve morphogenesis |
| pericardium development |
| cardiac right ventricle morphogenesis |
| endocardial cushion formation |
| pulmonary valve development |
| atrial septum development |
| positive regulation of cardiac muscle cell proliferation |
| atrioventricular valve development |
| aortic valve morphogenesis |
| outflow tract septum morphogenesis |
| branching involved in blood vessel morphogenesis |
| cardiac atrium morphogenesis |
| aortic valve development |
| positive regulation of cardiac muscle tissue growth |
| spinal cord motor neuron differentiation |
| endocardial cushion morphogenesis |
| cardiac atrium development |
| semi-lunar valve development |
| positive regulation of heart growth |
| regulation of cardiac muscle cell proliferation |
| endocardial cushion development |
| positive regulation of cardiac muscle tissue development |
| endoderm formation |
| ventral spinal cord development |
| positive regulation of organ growth |
| morphogenesis of an epithelial sheet |
| mesenchyme morphogenesis |
| heart valve morphogenesis |
| RNA polymerase II activating transcription factor binding |
| cell differentiation in spinal cord |
| regulation of cardiac muscle tissue growth |
| heart looping |
| heart valve development |
| RNA polymerase II transcription factor binding |
| regulation of heart growth |
| determination of heart left/right asymmetry |
| embryonic heart tube morphogenesis |
| mesoderm formation |
| cardiac muscle tissue morphogenesis |
| vasculogenesis |
| mesoderm morphogenesis |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle organ development |
| positive regulation of muscle tissue development |
| endoderm development |
| cardiac septum morphogenesis |
| outflow tract morphogenesis |
| cardiac ventricle morphogenesis |
| embryonic heart tube development |
| regulation of cardiac muscle tissue development |
| muscle tissue morphogenesis |
| dorsal/ventral pattern formation |
| muscle organ morphogenesis |
| cell fate specification |
| regulation of organ growth |
| spinal cord development |
| cardiac septum development |
| formation of primary germ layer |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| determination of left/right symmetry |
| neuron migration |
| determination of bilateral symmetry |
| mesoderm development |
| specification of symmetry |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| negative regulation of protein complex assembly |
| branching morphogenesis of an epithelial tube |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| morphogenesis of a branching epithelium |
| gastrulation |
| cardiac muscle tissue development |
| morphogenesis of a branching structure |
| cardiac chamber development |
| positive regulation of developmental growth |
| central nervous system neuron differentiation |
| mesenchyme development |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cell fate commitment |
| heart morphogenesis |
| muscle contraction |
| positive regulation of growth |
| striated muscle tissue development |
| embryonic organ morphogenesis |
| muscle organ development |
| muscle tissue development |
| muscle system process |
| epithelial tube morphogenesis |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| angiogenesis |
| regulation of developmental growth |
| regionalization |
| blood circulation |
| circulatory system process |
| blood vessel morphogenesis |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of protein complex assembly |
| muscle structure development |
| blood vessel development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| cardiovascular system development |
| heart development |
| cell population proliferation |
| tissue morphogenesis |
| embryonic morphogenesis |
| tube morphogenesis |
| regulation of growth |
| negative regulation of cellular component organization |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| cell migration |
| embryo development |
| central nervous system development |
| neuron differentiation |
| cell motility |
| localization of cell |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5982
- Expression level (log2 read counts): -7.68
Expression Distribution
TBX20 Expression in NALM6 Cells: -7.68
