TMEM108

Entrez Summary: N/A
UniProt Summary: Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF- dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. {ECO:0000250|UniProtKB:Q8BHE4}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of neurotrophin TRK receptor signaling pathway
cellular response to brain-derived neurotrophic factor stimulus
dendrite extension
somatodendritic compartment
regulation of neurotrophin TRK receptor signaling pathway
dentate gyrus development
postsynaptic density organization
retrograde axonal transport
postsynaptic specialization organization
modulation of excitatory postsynaptic potential
cellular response to nerve growth factor stimulus
response to nerve growth factor
axonal transport
axon cytoplasm
neuron projection extension
axo-dendritic transport
hippocampus development
postsynapse organization
developmental cell growth
cell growth
limbic system development
developmental growth involved in morphogenesis
regulation of nervous system process
transport along microtubule
pallium development
cytoskeleton-dependent intracellular transport
microtubule-based transport
postsynaptic membrane
endosome membrane
receptor-mediated endocytosis
postsynaptic density
early endosome
telencephalon development
synapse organization
microtubule-based movement
regulation of cellular response to growth factor stimulus
axon
forebrain development
developmental growth
growth