TNIK

Entrez Summary: Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Amiloride 100μM R08 exp447	-2.14
Tozasertib 0.1μM R07 exp414	-1.93
Actinomycin-D 0.01μM R00 exp4	-1.82
All-trans-Retinoic-Acid 8μM R07 exp333	-1.75
MSC2530818 10μM R07 exp379	-1.73
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.71
I-BRD9 4μM R07 exp365	1.85

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

activation of JNKK activity
microvillus assembly
postsynaptic density, intracellular component
microvillus organization
activation of MAPKK activity
actin cytoskeleton reorganization
positive regulation of JUN kinase activity
JNK cascade
regulation of JUN kinase activity
regulation of dendrite morphogenesis
presynapse
stress-activated MAPK cascade
recycling endosome
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
regulation of dendrite development
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
protein localization to plasma membrane
regulation of JNK cascade
protein autophosphorylation
protein localization to cell periphery
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
protein kinase activity
positive regulation of MAP kinase activity
regulation of cell morphogenesis involved in differentiation
apical plasma membrane
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
glutamatergic synapse
Wnt signaling pathway
cell-cell signaling by wnt
protein serine/threonine kinase activity
cytoskeleton
MAPK cascade
signal transduction by protein phosphorylation
cell surface receptor signaling pathway involved in cell-cell signaling
plasma membrane bounded cell projection assembly