WNK4

• Official Symbol: WNK4
• Official Name: WNK lysine deficient protein kinase 4
• Aliases and Previous Symbols: N/A
• Entrez ID: 65266
• UniProt: Q96J92
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009].
• UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 4956
• Expression level (log2 read counts): 1.81

Expression Distribution

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WNK4 Expression in NALM6 Cells: 1.81