WWC1

Entrez Summary: The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
UniProt Summary: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. {ECO:0000269|PubMed:15081397, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:18190796, ECO:0000269|PubMed:18596123, ECO:0000269|PubMed:18672031, ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:23778582}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Thioridazine 5μM R08 exp530	-1.71
All-trans-Retinoic-Acid 40μM R07 exp334	1.8

negative regulation of hippo signaling
regulation of hippo signaling
positive regulation of transcription of Notch receptor target
hippo signaling
negative regulation of organ growth
molecular adaptor activity
kinase binding
regulation of organ growth
ruffle membrane
negative regulation of developmental growth
establishment of cell polarity
Notch signaling pathway
establishment or maintenance of cell polarity
negative regulation of growth
transcription coactivator activity
regulation of developmental growth
regulation of intracellular transport
negative regulation of intracellular signal transduction
positive regulation of MAPK cascade
protein-containing complex
regulation of growth
perinuclear region of cytoplasm
regulation of MAPK cascade
negative regulation of transcription by RNA polymerase II
regulation of cellular localization
negative regulation of developmental process
cell migration
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
localization of cell
cell motility
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II
positive regulation of protein modification process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process