XPNPEP2
Gene Information
- Official Symbol: XPNPEP2
- Official Name: X-prolyl aminopeptidase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 7512
- UniProt: O43895
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008].
- UniProt Summary: Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin. {ECO:0000269|PubMed:15361070}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13748
- Expression level (log2 read counts): 1.78
XPNPEP2 Expression in NALM6 Cells: 1.78
