XRN1

Entrez Summary: N/A
UniProt Summary: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250|UniProtKB:P97789, ECO:0000269|PubMed:18172165}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 107/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	6/28
bone	2/26
breast	5/33
central nervous system	7/56
cervix	1/4
colorectal	2/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	3/21
liver	0/20
lung	15/75
lymphocyte	4/16
ovary	2/26
pancreas	1/24
peripheral nervous system	2/16
plasma cell	5/15
prostate	0/1
skin	3/24
soft tissue	1/9
thyroid	1/2
upper aerodigestive	7/22
urinary tract	1/29
uterus	1/5

Expression Distribution

Gene	Correlation
EDC4	0.405
HGC6.3	0.405

cellular response to puromycin
response to puromycin
5-3 exoribonuclease activity
cellular response to cycloheximide
response to cycloheximide
G-quadruplex RNA binding
G-quadruplex DNA binding
response to fungicide
nuclear mRNA surveillance
nuclear RNA surveillance
histone mRNA catabolic process
RNA surveillance
rRNA catabolic process
negative regulation of telomere maintenance via telomerase
telomerase RNA binding
negative regulation of telomere maintenance via telomere lengthening
ncRNA catabolic process
histone mRNA metabolic process
negative regulation of telomere maintenance
response to testosterone
negative regulation of DNA biosynthetic process
RNA phosphodiester bond hydrolysis, exonucleolytic
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
regulation of telomere maintenance
cellular response to alcohol
P-body
cellular response to ketone
response to antineoplastic agent
regulation of DNA biosynthetic process
cellular response to antibiotic
negative regulation of DNA metabolic process
negative regulation of translation
negative regulation of chromosome organization
negative regulation of cellular amide metabolic process
response to purine-containing compound
RNA phosphodiester bond hydrolysis
regulation of mRNA stability
regulation of RNA stability
response to ketone