ZNF131

Entrez Summary: N/A
UniProt Summary: Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. {ECO:0000250, ECO:0000269|PubMed:18847501, ECO:0000269|PubMed:22467880}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 229/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	9/28
blood	8/28
bone	9/26
breast	12/33
central nervous system	24/56
cervix	0/4
colorectal	1/17
esophagus	2/13
fibroblast	0/1
gastric	3/16
kidney	10/21
liver	5/20
lung	23/75
lymphocyte	3/16
ovary	13/26
pancreas	4/24
peripheral nervous system	5/16
plasma cell	4/15
prostate	1/1
skin	7/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	9/22
urinary tract	14/29
uterus	3/5

Expression Distribution

Screen	Score
Aphidicolin 0.4μM R08 exp440	-1.8
WYE-354 6μM R02 exp90	-1.77
Dimethyloxaloylglycine 100μM R05 exp229	-1.76

intermediate filament cytoskeleton
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II regulatory region sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process