ZNF296

Gene Information

Official Symbol: ZNF296
Official Name: zinc finger protein 296
Aliases and Previous Symbols: N/A
Entrez ID: 162979
UniProt: Q8WUU4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be a transcriptional corepressor with KLF4. {ECO:0000250|UniProtKB:E9Q6W4}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Arsenate 40μM R06 exp264	-3.12
CB-5083 0.4μM R08 exp468	-2.35
Tubacin 1.6μM R07 exp416	-2.35
Radicicol 0.16μM R05 exp242	-1.97
B02 10μM R08 exp453	-1.95
Cerivastatin 0.15μM R05 exp226	-1.9
Bortezomib 0.05μM R00 exp7	-1.74
Golgicide-A 4μM R03 exp122	-1.74
Fluvastatin 2.2μM R06 exp282	-1.73
Thapsigargin 0.005μM R07 exp407	1.8
iCRT14 30μM R08 exp492	1.9

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4513
Expression level (log2 read counts): 4.48

Expression Distribution

transcription factor binding
sequence-specific DNA binding
cellular component
spermatogenesis
male gamete generation
DNA-binding transcription factor activity
gamete generation
molecular function
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
negative regulation of transcription by RNA polymerase II
multi-organism reproductive process
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
reproductive process
reproduction
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process