ZRANB1

Entrez Summary: N/A
UniProt Summary: Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling. {ECO:0000269|PubMed:18281465, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22157957, ECO:0000269|PubMed:23827681}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Wortmannin 5μM R00 exp38	-2.28
Azithromycin 100μM R08 exp452	-1.76
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.79
2-Methoxyestradiol 0.55μM R07 exp310	1.82
UM0125461 0.74μM R02 exp84	1.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
HECTD1	0.461
MED13L	0.42

protein K33-linked deubiquitination
protein K29-linked deubiquitination
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
K63-linked polyubiquitin modification-dependent protein binding
protein K63-linked deubiquitination
thiol-dependent ubiquitinyl hydrolase activity
thiol-dependent ubiquitin-specific protease activity
positive regulation of Wnt signaling pathway
protein deubiquitination
protein modification by small protein removal
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of cell morphogenesis
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
intracellular membrane-bounded organelle
cellular macromolecule catabolic process
cell migration
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
regulation of anatomical structure morphogenesis
cell motility
localization of cell
cytoskeleton organization
cell-cell signaling
proteolysis
locomotion
movement of cell or subcellular component
positive regulation of signal transduction
organic substance catabolic process
cellular catabolic process
positive regulation of cell communication
positive regulation of signaling