ABHD17B

Entrez Summary: N/A
UniProt Summary: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913). {ECO:0000250|UniProtKB:Q7M759, ECO:0000269|PubMed:26701913}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-D1870 3.15μM R02 exp66	-2.14
Prochlorperazine 5.2μM R02 exp77	-1.87
proTAME 5μM R04 exp187	1.73
MKC9989 10μM R03 exp133	1.84
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2
Apcin 25μM plus proTAME 2μM R04 exp177	2.3

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

anchored component of postsynaptic recycling endosome membrane
anchored component of postsynaptic density membrane
negative regulation of protein localization to microtubule
regulation of protein localization to microtubule
protein depalmitoylation
palmitoyl-(protein) hydrolase activity
macromolecule depalmitoylation
positive regulation of protein localization to endosome
regulation of dendritic spine maintenance
regulation of protein localization to endosome
lipoprotein catabolic process
regulation of protein localization to synapse
protein palmitoylation
protein deacylation
macromolecule deacylation
recycling endosome membrane
protein lipidation
lipoprotein biosynthetic process
regulation of postsynapse organization
negative regulation of cellular protein localization
lipoprotein metabolic process
dendritic spine
protein acylation
regulation of synapse organization
regulation of synapse structure or activity
positive regulation of cellular protein localization
glutamatergic synapse
regulation of cellular protein localization
cell junction
protein catabolic process
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of cellular localization
regulation of protein localization
macromolecule catabolic process
organonitrogen compound catabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
organic substance catabolic process