ABHD6

Entrez Summary: N/A
UniProt Summary: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). {ECO:0000250|UniProtKB:Q8R2Y0, ECO:0000269|PubMed:22969151}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of endocannabinoid signaling pathway
lysobisphosphatidic acid metabolic process
monoacylglycerol catabolic process
monoacylglycerol metabolic process
acylglycerol lipase activity
alditol phosphate metabolic process
long-term synaptic depression
phospholipase activity
AMPA glutamate receptor complex
phospholipid catabolic process
neutral lipid catabolic process
acylglycerol catabolic process
integral component of postsynaptic membrane
negative regulation of cold-induced thermogenesis
glycerolipid catabolic process
negative regulation of synaptic transmission
GABA-ergic synapse
positive regulation of lipid biosynthetic process
acylglycerol metabolic process
neutral lipid metabolic process
mitochondrial membrane
late endosome membrane
organophosphate catabolic process
positive regulation of lipid metabolic process
regulation of G protein-coupled receptor signaling pathway
regulation of cold-induced thermogenesis
regulation of lipid biosynthetic process
regulation of synaptic plasticity
cellular lipid catabolic process
negative regulation of cell migration
negative regulation of cell motility
lipid catabolic process
lysosomal membrane
glycerophospholipid metabolic process
negative regulation of cellular component movement
negative regulation of locomotion
glutamatergic synapse
phospholipid metabolic process
glycerolipid metabolic process
regulation of lipid metabolic process