ACBD5

Entrez Summary: This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

autophagy of peroxisome
aggrephagy
fatty-acyl-CoA binding
selective autophagy
peroxisomal membrane
fatty acid catabolic process
peroxisome
monocarboxylic acid catabolic process
lipid binding
macroautophagy
cellular lipid catabolic process
autophagy
process utilizing autophagic mechanism
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
fatty acid metabolic process
small molecule catabolic process
monocarboxylic acid metabolic process
molecular function
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process
membrane