ACTN2
Gene Information
- Official Symbol: ACTN2
- Official Name: actinin alpha 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 88
- UniProt: P35609
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013].
- UniProt Summary: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Pfam Domains GO Terms
Pfam Domains
| CH |
| CAMSAP CH |
| efhand Ca insen |
| Spectrin |
GO Terms
| titin Z domain binding |
| phospholipase C-activating angiotensin-activated signaling pathway |
| actin filament uncapping |
| thyroid hormone receptor coactivator activity |
| microspike assembly |
| FATZ binding |
| positive regulation of endocytic recycling |
| LIM domain binding |
| angiotensin-activated signaling pathway |
| regulation of endocytic recycling |
| negative regulation of protein localization to cell surface |
| positive regulation of actin filament depolymerization |
| titin binding |
| pseudopodium |
| postsynaptic density, intracellular component |
| negative regulation of potassium ion transmembrane transporter activity |
| positive regulation of protein depolymerization |
| cellular response to angiotensin |
| postsynaptic density membrane |
| positive regulation of potassium ion transmembrane transporter activity |
| negative regulation of potassium ion transmembrane transport |
| response to angiotensin |
| cell-substrate adherens junction assembly |
| focal adhesion assembly |
| negative regulation of potassium ion transport |
| adherens junction assembly |
| regulation of NMDA receptor activity |
| positive regulation of protein complex disassembly |
| muscle filament sliding |
| positive regulation of potassium ion transmembrane transport |
| actin-myosin filament sliding |
| regulation of protein localization to cell surface |
| cell-substrate junction assembly |
| positive regulation of potassium ion transport |
| structural constituent of muscle |
| sarcomere organization |
| regulation of actin filament depolymerization |
| cortical actin cytoskeleton |
| regulation of potassium ion transmembrane transporter activity |
| cardiac muscle cell development |
| regulation of glutamate receptor signaling pathway |
| cardiac cell development |
| myofibril assembly |
| platelet alpha granule lumen |
| positive regulation of cation channel activity |
| negative regulation of ion transmembrane transporter activity |
| filopodium |
| regulation of neurotransmitter receptor activity |
| cytoskeletal protein binding |
| phosphatidylinositol-4,5-bisphosphate binding |
| negative regulation of transporter activity |
| regulation of potassium ion transmembrane transport |
| actin filament |
| negative regulation of cation transmembrane transport |
| adherens junction organization |
| regulation of protein depolymerization |
| cardiac muscle cell differentiation |
| actin-mediated cell contraction |
| protein homotetramerization |
| negative regulation of ion transmembrane transport |
| regulation of potassium ion transport |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| positive regulation of ion transmembrane transporter activity |
| cellular component assembly involved in morphogenesis |
| actin filament-based movement |
| positive regulation of transporter activity |
| negative regulation of cellular protein localization |
| regulation of protein complex disassembly |
| actomyosin structure organization |
| cardiocyte differentiation |
| negative regulation of transmembrane transport |
| ion channel binding |
| cell-matrix adhesion |
| platelet degranulation |
| integrin binding |
| Z disc |
| striated muscle cell development |
| positive regulation of cation transmembrane transport |
| negative regulation of ion transport |
| dendritic spine |
| muscle cell development |
| protein tetramerization |
| positive regulation of ion transmembrane transport |
| protein dimerization activity |
| cardiac muscle tissue development |
| cell junction assembly |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| regulation of actin polymerization or depolymerization |
| protein localization to plasma membrane |
| regulation of actin filament length |
| cell-substrate adhesion |
| positive regulation of supramolecular fiber organization |
| striated muscle cell differentiation |
| positive regulation of transmembrane transport |
| actin filament binding |
| positive regulation of intracellular transport |
| cell junction organization |
| positive regulation of cytoskeleton organization |
| protein localization to cell periphery |
| protein domain specific binding |
| muscle cell differentiation |
| muscle contraction |
| regulation of ion transmembrane transporter activity |
| regulation of actin filament organization |
| regulation of transmembrane transporter activity |
| cellular response to peptide hormone stimulus |
| positive regulation of ion transport |
| regulation of transporter activity |
| striated muscle tissue development |
| muscle tissue development |
| muscle system process |
| cellular response to peptide |
| regulation of cation transmembrane transport |
| protein homooligomerization |
| regulation of actin cytoskeleton organization |
| glutamatergic synapse |
| regulation of supramolecular fiber organization |
| regulation of intracellular transport |
| cytoskeleton |
| MAPK cascade |
| regulation of cellular component size |
| regulation of metal ion transport |
| regulation of actin filament-based process |
| response to peptide hormone |
| signal transduction by protein phosphorylation |
| focal adhesion |
| regulation of membrane potential |
| plasma membrane bounded cell projection assembly |
| supramolecular fiber organization |
| cell projection assembly |
| response to peptide |
| muscle structure development |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| negative regulation of transport |
| actin cytoskeleton organization |
| regulation of anatomical structure size |
| protein complex oligomerization |
| heart development |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| regulation of vesicle-mediated transport |
| regulation of transmembrane transport |
| actin filament-based process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| positive regulation of organelle organization |
| cellular response to nitrogen compound |
| regulation of ion transport |
| regulated exocytosis |
| calcium ion binding |
| organelle assembly |
| exocytosis |
| cellular component morphogenesis |
| circulatory system development |
| protein homodimerization activity |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| regulation of cellular localization |
| cell adhesion |
| biological adhesion |
| protein phosphorylation |
| positive regulation of transport |
| response to organonitrogen compound |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| cellular response to oxygen-containing compound |
| identical protein binding |
| response to nitrogen compound |
| cytoskeleton organization |
| secretion |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| cell projection organization |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| phosphorylation |
| regulation of organelle organization |
| G protein-coupled receptor signaling pathway |
| response to endogenous stimulus |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of RNA metabolic process |
| tissue development |
| positive regulation of molecular function |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pterostilbene 16μM R02 exp78 | -2.09 |
| OICR-9429 10μM R03 exp142 | 1.83 |
| A-196 10μM R03 exp114 | 1.92 |
| BI-2536 0.0042μM R03 exp95 | 1.94 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13365
- Expression level (log2 read counts): -1.65
Expression Distribution
ACTN2 Expression in NALM6 Cells: -1.65
