ACTR1B

Entrez Summary: N/A
UniProt Summary: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

microtubule cortical anchor activity
nuclear migration along microtubule
dynactin complex
cell cortex region
nuclear migration
nucleus localization
establishment of mitotic spindle orientation
establishment of mitotic spindle localization
establishment of spindle orientation
establishment of spindle localization
spindle localization
organelle transport along microtubule
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
microtubule cytoskeleton organization involved in mitosis
secretory granule lumen
establishment of cell polarity
ficolin-1-rich granule lumen
microtubule cytoskeleton
transport along microtubule
cytoskeleton-dependent intracellular transport
antigen processing and presentation of exogenous peptide antigen
microtubule-based transport
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
establishment or maintenance of cell polarity
antigen processing and presentation
microtubule-based movement
establishment of organelle localization
microtubule cytoskeleton organization
neutrophil degranulation
centrosome
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response