ADAM2

Entrez Summary: N/A
UniProt Summary: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

fusion of sperm to egg plasma membrane involved in single fertilization
plasma membrane fusion
binding of sperm to zona pellucida
visual learning
sperm-egg recognition
visual behavior
metallopeptidase activity
cell-cell recognition
associative learning
metalloendopeptidase activity
membrane fusion
integrin binding
single fertilization
adult behavior
learning
fertilization
cell recognition
learning or memory
cognition
response to light stimulus
cellular process involved in reproduction in multicellular organism
response to radiation
behavior
protein-containing complex
cell surface
sexual reproduction
multicellular organism reproduction
membrane organization
cell adhesion
biological adhesion
multi-organism reproductive process
response to abiotic stimulus
proteolysis
nervous system process
integral component of plasma membrane
reproductive process
reproduction
system process
positive regulation of gene expression