ALDH1L2

Entrez Summary: This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hydroxymethyl-, formyl- and related transferase activity
formyltetrahydrofolate dehydrogenase activity
10-formyltetrahydrofolate catabolic process
folic acid-containing compound catabolic process
pteridine-containing compound catabolic process
10-formyltetrahydrofolate metabolic process
aldehyde dehydrogenase (NAD) activity
coenzyme catabolic process
dicarboxylic acid catabolic process
tetrahydrofolate metabolic process
folic acid metabolic process
one-carbon metabolic process
folic acid-containing compound metabolic process
cellular modified amino acid catabolic process
pteridine-containing compound metabolic process
cofactor catabolic process
water-soluble vitamin metabolic process
dicarboxylic acid metabolic process
vitamin metabolic process
cellular modified amino acid metabolic process
coenzyme metabolic process
carboxylic acid catabolic process
organic acid catabolic process
mitochondrial matrix
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
cofactor metabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
drug metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
mitochondrion
small molecule metabolic process
organic substance catabolic process