AMACR

Entrez Summary: This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

alpha-methylacyl-CoA racemase activity
fatty acid beta-oxidation using acyl-CoA oxidase
bile acid biosynthetic process
bile acid metabolic process
peroxisomal matrix
fatty acid beta-oxidation
protein localization to peroxisome
protein targeting to peroxisome
establishment of protein localization to peroxisome
peroxisomal transport
fatty acid oxidation
lipid oxidation
peroxisome organization
fatty acid catabolic process
peroxisome
monocarboxylic acid catabolic process
steroid biosynthetic process
organic hydroxy compound biosynthetic process
monocarboxylic acid biosynthetic process
cellular lipid catabolic process
lipid modification
steroid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
protein targeting
establishment of protein localization to organelle
small molecule catabolic process
organic hydroxy compound metabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
intracellular membrane-bounded organelle
protein localization to organelle
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process