ANAPC13

Entrez Summary: N/A
UniProt Summary: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:15060174, ECO:0000269|PubMed:18485873}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 105/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	5/28
blood	4/28
bone	6/26
breast	3/33
central nervous system	8/56
cervix	0/4
colorectal	2/17
esophagus	0/13
fibroblast	0/1
gastric	3/16
kidney	4/21
liver	3/20
lung	11/75
lymphocyte	2/16
ovary	3/26
pancreas	1/24
peripheral nervous system	5/16
plasma cell	0/15
prostate	0/1
skin	4/24
soft tissue	0/9
thyroid	1/2
upper aerodigestive	5/22
urinary tract	2/29
uterus	3/5

Expression Distribution

anaphase-promoting complex
protein K11-linked ubiquitination
protein polyubiquitination
cell division
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
cell cycle