ANO4

Entrez Summary: N/A
UniProt Summary: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. {ECO:0000250|UniProtKB:Q8C5H1}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

calcium activated phosphatidylserine scrambling
calcium activated galactosylceramide scrambling
calcium activated phosphatidylcholine scrambling
calcium activated phospholipid scrambling
phospholipid scramblase activity
intracellular calcium activated chloride channel activity
plasma membrane phospholipid scrambling
phospholipid translocation
lipid translocation
regulation of membrane lipid distribution
phospholipid transport
plasma membrane organization
chloride transport
organophosphate ester transport
protein dimerization activity
inorganic anion transport
lipid transport
lipid localization
endomembrane system organization
organic anion transport
anion transport
membrane organization
ion transmembrane transport
transmembrane transport
ion transport