AP1S2
Gene Information
- Official Symbol: AP1S2
- Official Name: adaptor related protein complex 1 subunit sigma 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 8905
- UniProt: P56377
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013].
- UniProt Summary: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16452
- Expression level (log2 read counts): 4.74
AP1S2 Expression in NALM6 Cells: 4.74
