AQP10

Entrez Summary: N/A
UniProt Summary: Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol. {ECO:0000269|PubMed:11573934, ECO:0000269|PubMed:12084581}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
INK128 0.2μM R02 exp70	-2.32
Benzoate 10000μM R08 exp455	1.8

glycerol channel activity
glycerol transport
urea transmembrane transport
urea transmembrane transporter activity
urea transport
cellular response to acidic pH
polyol transport
water channel activity
one-carbon compound transport
water transport
response to acidic pH
cellular response to pH
fluid transport
response to pH
carbohydrate transport
lipid droplet
protein homotetramerization
organic hydroxy compound transport
protein tetramerization
cellular response to environmental stimulus
cellular response to abiotic stimulus
apical plasma membrane
protein homooligomerization
response to toxic substance
protein complex oligomerization
response to abiotic stimulus
transmembrane transport
integral component of plasma membrane
protein-containing complex assembly
amide transport
nitrogen compound transport
protein-containing complex subunit organization