ARFGAP3

Entrez Summary: N/A
UniProt Summary: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. {ECO:0000269|PubMed:11172815}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.89
Dynasore 7μM R08 exp436	1.81
CAY10603 0.55μM R08 exp467	1.83
Menadione 5μM R06 exp292	1.92
UM0129480 7μM R02 exp85	2.1

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

COPI-coated vesicle budding
COPI coating of Golgi vesicle
Golgi transport vesicle coating
COPI vesicle coat
vesicle coating
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
vesicle targeting
vesicle budding from membrane
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
trans-Golgi network
peptide secretion
establishment of vesicle localization
vesicle localization
endoplasmic reticulum to Golgi vesicle-mediated transport
GTPase activator activity
vesicle organization
establishment of organelle localization
Golgi vesicle transport
positive regulation of GTPase activity
regulation of GTPase activity
organelle localization
Golgi membrane
positive regulation of hydrolase activity
membrane organization
Golgi apparatus
intracellular protein transport
secretion by cell
export from cell
secretion
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization