ARHGAP10

Entrez Summary: N/A
UniProt Summary: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). {ECO:0000250, ECO:0000269|PubMed:11432776}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
WNT3A 44ng/ml R08 exp537	1.71
Chloramphenicol 20μM R00 exp13	1.73
ABT-702 5μM plus CoCl2 18μM R07 exp320	1.74
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.99

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SH3 1
RhoGAP

GTPase activator activity
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
regulation of GTPase activity
perinuclear region of cytoplasm
positive regulation of hydrolase activity
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
cytoskeleton organization
regulation of hydrolase activity
positive regulation of catalytic activity
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
positive regulation of molecular function
regulation of intracellular signal transduction