ARID5B

Entrez Summary: This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cincreasin 100μM R08 exp473	1.74
FK-506 30μM R07 exp359	2

fat pad development
fibroblast migration
adrenal gland development
face morphogenesis
platelet-derived growth factor receptor signaling pathway
adipose tissue development
head morphogenesis
body morphogenesis
face development
multicellular organism growth
muscle organ morphogenesis
female gonad development
post-embryonic development
roof of mouth development
development of primary female sexual characteristics
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
fat cell differentiation
female sex differentiation
endocrine system development
liver development
hepaticobiliary system development
male gonad development
development of primary male sexual characteristics
male sex differentiation
ameboidal-type cell migration
gonad development
development of primary sexual characteristics
transcription regulatory region DNA binding
connective tissue development
skeletal system morphogenesis
DNA-binding transcription repressor activity, RNA polymerase II-specific
positive regulation of DNA-binding transcription factor activity
sex differentiation
kidney development
transcription coactivator activity
renal system development
muscle organ development
RNA polymerase II regulatory region sequence-specific DNA binding
urogenital system development