ASAP1

Gene Information

Official Symbol: ASAP1
Official Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Aliases and Previous Symbols: N/A
Entrez ID: 50807
UniProt: Q9ULH1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: Possesses phosphatidylinositol 4,5-bisphosphate- dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity). Plays a role in ciliogenesis. {ECO:0000250, ECO:0000269|PubMed:20393563}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8383
Expression level (log2 read counts): 5.9

Expression Distribution

Screen	Score
Cisplatin 0.35μM R06 exp273	-1.92
Doxorubicin 0.02μM R08 exp478	-1.72
NFN1 0.4μM R03 exp99	1.78
Trientine 500μM R08 exp534	1.95

PH
SH3 2
ArfGap
Ank 2
SH3 1

positive regulation of membrane tubulation
regulation of membrane tubulation
cell projection membrane
positive regulation of podosome assembly
negative regulation of dendritic spine development
regulation of plasma membrane organization
regulation of podosome assembly
negative regulation of dendrite development
podosome
phosphatidylinositol-3,4,5-trisphosphate binding
phosphatidylserine binding
regulation of dendritic spine development
positive regulation of organelle assembly
phosphatidylinositol-4,5-bisphosphate binding
dendritic spine
regulation of dendrite development
negative regulation of neuron projection development
negative regulation of cell projection organization
regulation of organelle assembly
negative regulation of neuron differentiation
positive regulation of protein complex assembly
GTPase activator activity
negative regulation of neurogenesis
cadherin binding
negative regulation of nervous system development
negative regulation of cell development
cilium assembly
cilium organization
positive regulation of GTPase activity
plasma membrane bounded cell projection assembly
regulation of protein complex assembly
cell projection assembly
regulation of GTPase activity
regulation of neuron projection development
positive regulation of cellular component biogenesis
positive regulation of organelle organization
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization