ATAD2B

Entrez Summary: The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.94
Latrunculin-B 10μM R07 exp374	-1.82
Atovaquone 15μM R08 exp451	-1.7
ABT-702 0.1μM R06 exp260	1.78
Nifurtimox 1μM R03 exp141	1.8
Golgicide-A 2μM R03 exp121	1.8
HMS-I2 10μM R06 exp288	1.88
NFN1 1μM R03 exp100	1.89

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Bromodomain
AAA

lysine-acetylated histone binding
negative regulation of chromatin silencing
negative regulation of gene silencing
regulation of chromatin silencing
negative regulation of chromatin organization
positive regulation of gene expression, epigenetic
regulation of gene silencing
histone binding
negative regulation of chromosome organization
regulation of chromatin organization
ATPase activity
regulation of gene expression, epigenetic
regulation of chromosome organization
negative regulation of organelle organization
chromatin binding
negative regulation of cellular component organization
positive regulation of transcription by RNA polymerase II
regulation of organelle organization
ATP binding
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process