ATOX1

Entrez Summary: N/A
UniProt Summary: Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Artemisinin 50μM R08 exp450	1.7
Trientine 500μM R08 exp534	5.56
Ammonium tetrathiomolybdate 10μM R08 exp448	6.64

metallochaperone activity
copper ion export
copper chaperone activity
copper-dependent protein binding
copper ion transmembrane transport
cellular copper ion homeostasis
copper ion transport
copper ion homeostasis
copper ion binding
ATPase binding
cellular transition metal ion homeostasis
transition metal ion transport
transition metal ion homeostasis
response to oxidative stress
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cation transport
negative regulation of apoptotic process
cellular homeostasis
negative regulation of programmed cell death
ion transmembrane transport
negative regulation of cell death
chemical homeostasis
transmembrane transport
ion transport
regulation of apoptotic process
regulation of programmed cell death
homeostatic process
regulation of cell death