ATPAF2

Entrez Summary: This gene encodes an assembly factor for the F(1) component of the mitochondrial ATP synthase. This protein binds specifically to the F1 alpha subunit and is thought to prevent this subunit from forming nonproductive homooligomers during enzyme assembly. This gene is located within the Smith-Magenis syndrome region on chromosome 17. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase). {ECO:0000269|PubMed:11410595}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	1.71
5-Azacytidine 2μM R07 exp330	1.72
Arsenate 40μM R06 exp264	1.72
PU-H71 1μM R08 exp515	1.77
Rotenone 0.07μM R08 exp431	1.77
CB-5083 0.4μM R08 exp468	1.8
Deferoxamine 11μM R07 exp350	1.89
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.06
Citral 75μM R06 exp275	3.18

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

proton-transporting ATP synthase complex assembly
proton-transporting two-sector ATPase complex assembly
nuclear speck
cellular protein-containing complex assembly
mitochondrion
protein-containing complex assembly
protein-containing complex subunit organization