B3GNT8

Official Symbol: B3GNT8
Official Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
Aliases and Previous Symbols: N/A
Entrez ID: 374907
UniProt: Q7Z7M8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans. {ECO:0000269|PubMed:15620693, ECO:0000269|PubMed:15917431}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.75
Resveratrol 16μM R03 exp147	1.89

protein N-acetylglucosaminyltransferase activity
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity
poly-N-acetyllactosamine biosynthetic process
poly-N-acetyllactosamine metabolic process
galactosyltransferase activity
acetylgalactosaminyltransferase activity
polysaccharide biosynthetic process
cellular polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
O-glycan processing
cellular polysaccharide metabolic process
polysaccharide metabolic process
aminoglycan biosynthetic process
protein O-linked glycosylation
carbohydrate biosynthetic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
Golgi apparatus
endoplasmic reticulum
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process