BIRC3

Gene Information

Official Symbol: BIRC3
Official Name: baculoviral IAP repeat containing 3
Aliases and Previous Symbols: N/A
Entrez ID: 330
UniProt: Q13489
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. {ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
HMS-I1 10μM R06 exp256	-1.82
Rifampicin 10μM R00 exp32	1.76
CCCP 1μM R00 exp11	1.81
Bisphenol S 100μM R08 exp458	1.94
Brefeldin A 0.02μM R00 exp8	1.98
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.06

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14905
Expression level (log2 read counts): 1.64

Expression Distribution

BIR
CARD

inhibition of cysteine-type endopeptidase activity involved in apoptotic process
regulation of nucleotide-binding oligomerization domain containing signaling pathway
negative regulation of necroptotic process
inhibition of cysteine-type endopeptidase activity
zymogen inhibition
negative regulation of programmed necrotic cell death
negative regulation of necrotic cell death
regulation of necroptotic process
regulation of RIG-I signaling pathway
regulation of programmed necrotic cell death
regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
regulation of necrotic cell death
TRIF-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
negative regulation of protein maturation
negative regulation of protein processing
regulation of tumor necrosis factor-mediated signaling pathway
transferase activity
regulation of protein processing
regulation of toll-like receptor signaling pathway
regulation of protein maturation
I-kappaB kinase/NF-kappaB signaling
regulation of defense response to virus
NIK/NF-kappaB signaling
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cysteine-type endopeptidase activity
toll-like receptor signaling pathway
protein heterooligomerization
positive regulation of protein ubiquitination
tumor necrosis factor-mediated signaling pathway
pattern recognition receptor signaling pathway
positive regulation of protein modification by small protein conjugation or removal
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein ubiquitination
regulation of cysteine-type endopeptidase activity involved in apoptotic process
ubiquitin protein ligase activity
membrane raft