C22orf29

Entrez Summary: N/A
UniProt Summary: Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity. {ECO:0000269|PubMed:23055042}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
SNS-032 25μM R07 exp401	-2.3
2-Deoxy-D-glucose 800μM R05 exp214	-1.71

mitochondrial outer membrane permeabilization
positive regulation of mitochondrial membrane permeability involved in apoptotic process
mitochondrial outer membrane permeabilization involved in programmed cell death
positive regulation of mitochondrial membrane permeability
positive regulation of membrane permeability
regulation of mitochondrial membrane permeability involved in apoptotic process
apoptotic mitochondrial changes
regulation of mitochondrial membrane potential
regulation of mitochondrial membrane permeability
regulation of membrane permeability
mitochondrial membrane organization
mitochondrial transport
apoptotic signaling pathway
regulation of membrane potential
mitochondrion organization
membrane organization
apoptotic process
programmed cell death
cell death
mitochondrion