C3
Gene Information
- Official Symbol: C3
- Official Name: complement C3
- Aliases and Previous Symbols: N/A
- Entrez ID: 718
- UniProt: P01024
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015].
- UniProt Summary: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| A2M N |
| A2M N 2 |
| Thiol-ester cl |
| NTR |
| ANATO |
| A2M recep |
| A2M comp |
| A2M |
GO Terms
| C5L2 anaphylatoxin chemotactic receptor binding |
| complement-dependent cytotoxicity |
| positive regulation of activation of membrane attack complex |
| vertebrate eye-specific patterning |
| positive regulation of type II hypersensitivity |
| regulation of activation of membrane attack complex |
| positive regulation of type IIa hypersensitivity |
| regulation of type II hypersensitivity |
| regulation of type IIa hypersensitivity |
| complement-mediated synapse pruning |
| positive regulation of complement activation |
| positive regulation of hypersensitivity |
| positive regulation of apoptotic cell clearance |
| positive regulation of acute inflammatory response to antigenic stimulus |
| regulation of hypersensitivity |
| regulation of apoptotic cell clearance |
| synapse pruning |
| neuron remodeling |
| positive regulation of inflammatory response to antigenic stimulus |
| complement activation, alternative pathway |
| regulation of acute inflammatory response to antigenic stimulus |
| positive regulation of membrane invagination |
| positive regulation of phagocytosis, engulfment |
| regulation of phagocytosis, engulfment |
| regulation of membrane invagination |
| regulation of triglyceride biosynthetic process |
| positive regulation of humoral immune response |
| positive regulation of lipid storage |
| amyloid-beta clearance |
| regulation of inflammatory response to antigenic stimulus |
| positive regulation of G protein-coupled receptor signaling pathway |
| positive regulation of vascular endothelial growth factor production |
| positive regulation of acute inflammatory response |
| positive regulation of myeloid leukocyte mediated immunity |
| regulation of vascular endothelial growth factor production |
| endopeptidase inhibitor activity |
| regulation of triglyceride metabolic process |
| positive regulation of B cell mediated immunity |
| positive regulation of immunoglobulin mediated immune response |
| neuron maturation |
| positive regulation of glucose transmembrane transport |
| regulation of acute inflammatory response |
| regulation of lipid storage |
| regulation of B cell mediated immunity |
| regulation of immunoglobulin mediated immune response |
| positive regulation of receptor-mediated endocytosis |
| regulation of myeloid leukocyte mediated immunity |
| positive regulation of phagocytosis |
| regulation of glucose transmembrane transport |
| positive regulation of lipid localization |
| cell killing |
| azurophil granule lumen |
| regulation of phagocytosis |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of endocytosis |
| regulation of receptor-mediated endocytosis |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| secretory granule lumen |
| regulation of complement activation |
| positive regulation of leukocyte mediated immunity |
| anatomical structure maturation |
| regulation of humoral immune response |
| regulation of lipid localization |
| positive regulation of inflammatory response |
| blood microparticle |
| regulation of G protein-coupled receptor signaling pathway |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of lymphocyte mediated immunity |
| cell maturation |
| regulation of adaptive immune response |
| complement activation, classical pathway |
| positive regulation of angiogenesis |
| humoral immune response mediated by circulating immunoglobulin |
| complement activation |
| positive regulation of vasculature development |
| regulation of lipid biosynthetic process |
| positive regulation of transmembrane transport |
| regulation of endocytosis |
| regulation of leukocyte mediated immunity |
| immunoglobulin mediated immune response |
| B cell mediated immunity |
| positive regulation of immune effector process |
| developmental maturation |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| lymphocyte mediated immunity |
| synapse organization |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of angiogenesis |
| endoplasmic reticulum lumen |
| regulation of vasculature development |
| fatty acid metabolic process |
| regionalization |
| signaling receptor binding |
| regulation of inflammatory response |
| humoral immune response |
| negative regulation of proteolysis |
| visual system development |
| post-translational protein modification |
| sensory system development |
| regulation of lipid metabolic process |
| cellular component disassembly |
| regulation of endopeptidase activity |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| pattern specification process |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| negative regulation of hydrolase activity |
| regulation of immune effector process |
| positive regulation of defense response |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| inflammatory response |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| monocarboxylic acid metabolic process |
| regulation of vesicle-mediated transport |
| regulation of transmembrane transport |
| myeloid leukocyte activation |
| protein-containing complex |
| positive regulation of response to external stimulus |
| adaptive immune response |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| activation of immune response |
| response to bacterium |
| regulation of cytokine production |
| regulated exocytosis |
| regulation of proteolysis |
| regulation of defense response |
| leukocyte mediated immunity |
| innate immune response |
| negative regulation of catalytic activity |
| exocytosis |
| neuron development |
| positive regulation of immune response |
| carboxylic acid metabolic process |
| leukocyte activation |
| defense response to other organism |
| cellular lipid metabolic process |
| central nervous system development |
| positive regulation of transport |
| oxoacid metabolic process |
| secretion by cell |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| organic acid metabolic process |
| negative regulation of cellular protein metabolic process |
| export from cell |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of cellular component organization |
| lipid metabolic process |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pimelic-diphenylamide-106 0.5μM R00 exp27 | 1.8 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2615
- Expression level (log2 read counts): 2.53
Expression Distribution
C3 Expression in NALM6 Cells: 2.53
