CAB39
Gene Information
- Official Symbol: CAB39
- Official Name: calcium binding protein 39
- Aliases and Previous Symbols: N/A
- Entrez ID: 51719
- UniProt: Q9Y376
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. {ECO:0000269|PubMed:19892943}.
Pfam Domains GO Terms
Pfam Domains
| Mo25 |
GO Terms
| serine/threonine protein kinase complex |
| cellular hypotonic response |
| hypotonic response |
| negative regulation of potassium ion transmembrane transporter activity |
| negative regulation of potassium ion transmembrane transport |
| protein kinase activator activity |
| protein serine/threonine kinase activator activity |
| positive regulation of peptidyl-threonine phosphorylation |
| negative regulation of potassium ion transport |
| cellular response to osmotic stress |
| regulation of peptidyl-threonine phosphorylation |
| regulation of potassium ion transmembrane transporter activity |
| negative regulation of ion transmembrane transporter activity |
| response to osmotic stress |
| negative regulation of transporter activity |
| regulation of potassium ion transmembrane transport |
| negative regulation of cation transmembrane transport |
| kinase binding |
| negative regulation of ion transmembrane transport |
| regulation of potassium ion transport |
| protein heterooligomerization |
| secretory granule lumen |
| negative regulation of transmembrane transport |
| ficolin-1-rich granule lumen |
| cell cycle arrest |
| negative regulation of ion transport |
| peptidyl-serine phosphorylation |
| peptidyl-serine modification |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of transporter activity |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| activation of protein kinase activity |
| regulation of cation transmembrane transport |
| positive regulation of protein serine/threonine kinase activity |
| protein serine/threonine kinase activity |
| regulation of metal ion transport |
| signal transduction by protein phosphorylation |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| myeloid cell activation involved in immune response |
| positive regulation of protein kinase activity |
| regulation of transmembrane transport |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| positive regulation of transferase activity |
| regulation of ion transport |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| regulation of protein kinase activity |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| leukocyte activation |
| protein phosphorylation |
| regulation of transferase activity |
| cell cycle process |
| secretion by cell |
| positive regulation of protein phosphorylation |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| immune effector process |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| response to abiotic stimulus |
| regulation of cell cycle |
| positive regulation of protein modification process |
| phosphorylation |
| cell cycle |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| protein-containing complex assembly |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Adefovir 20μM R07 exp332 | -2.09 |
| CR131-b 0.005μM R08 exp474 | -1.77 |
| UMK57 1μM R01 exp59 | -1.74 |
| CHIR-124 0.04μM R06 exp272 | 1.78 |
| Phenformin 20μM R03 exp143 | 1.78 |
| Oligomycin-A 20μM R00 exp26 | 2.11 |
| MLN-4924 0.2μM R00 exp21 | 2.15 |
| SGC0649 7μM R03 exp150 | 2.24 |
| Arsenate 40μM R06 exp264 | 2.6 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 12/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 2/28 |
| bone | 1/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 1/21 |
| liver | 1/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1652
- Expression level (log2 read counts): 6.7
Expression Distribution
CAB39 Expression in NALM6 Cells: 6.7
