CABP1

Gene Information

Official Symbol: CABP1
Official Name: calcium binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 9478
UniProt: Q9NZU7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012].
UniProt Summary: Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88751, ECO:0000269|PubMed:11865310, ECO:0000269|PubMed:14570872, ECO:0000269|PubMed:15140941, ECO:0000269|PubMed:15895247, ECO:0000269|PubMed:15980432}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5707
Expression level (log2 read counts): 1.74

Expression Distribution

Screen	Score
UM0130462 0.025 to 0.035μM day4 R05 exp247	1.75
SNS-032 15μM R08 exp443	1.86
CAY10603 0.55μM R08 exp467	2.09

negative regulation of protein import
negative regulation of protein import into nucleus
negative regulation of nucleocytoplasmic transport
nuclear localization sequence binding
negative regulation of protein localization to nucleus
enzyme inhibitor activity
negative regulation of intracellular protein transport
regulation of protein import into nucleus
regulation of protein import
negative regulation of intracellular transport
calcium-dependent protein binding
regulation of nucleocytoplasmic transport
negative regulation of cellular protein localization
regulation of protein localization to nucleus
cell cortex
negative regulation of protein transport
negative regulation of establishment of protein localization
postsynaptic membrane
visual perception
sensory perception of light stimulus
regulation of intracellular protein transport
postsynaptic density
regulation of intracellular transport
cytoskeleton
negative regulation of transport
regulation of cellular protein localization
cell junction
Golgi membrane
perinuclear region of cytoplasm
regulation of protein transport
calcium ion binding
regulation of peptide transport
regulation of establishment of protein localization
negative regulation of catalytic activity
regulation of cellular localization
sensory perception
regulation of protein localization
negative regulation of molecular function
nervous system process
extracellular space