CACNA2D1

Gene Information

Official Symbol: CACNA2D1
Official Name: calcium voltage-gated channel auxiliary subunit alpha2delta 1
Aliases and Previous Symbols: N/A
Entrez ID: 781
UniProt: P54289
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014].
UniProt Summary: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5572
Expression level (log2 read counts): -5.6

Expression Distribution

Screen	Score
R-DABN 8μM R03 exp111	-1.87
TRAIL 5ng/ml R00 exp35	1.85
Cyclosporin-A 3μM R07 exp348	1.94

VGCC alpha2
VWA N
VWA
Cache 1

voltage-gated calcium channel activity involved in bundle of His cell action potential
membrane depolarization during bundle of His cell action potential
calcium ion transmembrane transport via high voltage-gated calcium channel
voltage-gated calcium channel activity involved in cardiac muscle cell action potential
bundle of His cell action potential
bundle of His cell to Purkinje myocyte signaling
positive regulation of high voltage-gated calcium channel activity
regulation of membrane repolarization during action potential
calcium ion import across plasma membrane
calcium ion import into cytosol
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
positive regulation of voltage-gated calcium channel activity
L-type voltage-gated calcium channel complex
bundle of His cell to Purkinje myocyte communication
regulation of high voltage-gated calcium channel activity
membrane depolarization during cardiac muscle cell action potential
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of cardiac muscle cell membrane repolarization
cell-cell signaling involved in cardiac conduction
voltage-gated calcium channel complex
membrane depolarization during action potential
regulation of membrane repolarization
regulation of voltage-gated calcium channel activity
regulation of heart rate by cardiac conduction
positive regulation of calcium ion transmembrane transporter activity
cardiac muscle cell action potential involved in contraction
cellular response to amyloid-beta
voltage-gated calcium channel activity
cardiac muscle cell contraction
calcium ion import
sarcoplasmic reticulum
cell communication involved in cardiac conduction
regulation of action potential
response to amyloid-beta
cardiac muscle cell action potential
membrane depolarization
calcium ion transmembrane import into cytosol
positive regulation of cation channel activity
positive regulation of calcium ion transmembrane transport
calcium ion transport into cytosol