CAPNS2

Entrez Summary: N/A
UniProt Summary: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ETC-159 50μM R08 exp480	-1.93
Pyridostatin 4μM R05 exp240	-1.91
QNZ 0.01μM R08 exp439	-1.88
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.7
Pifithrin-alpha 20μM R07 exp390	1.83
Senexin-A 25μM R07 exp400	2.13

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

calcium-dependent cysteine-type endopeptidase activity
extracellular matrix disassembly
extracellular matrix organization
extracellular structure organization
cellular component disassembly
calcium ion binding
proteolysis