CATSPER1

Entrez Summary: Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008].
UniProt Summary: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PKD channel
Ion trans

regulation of cilium movement involved in cell motility
regulation of cilium beat frequency involved in ciliary motility
CatSper complex
regulation of cilium beat frequency
calcium activated cation channel activity
regulation of cilium movement
regulation of cilium-dependent cell motility
regulation of microtubule-based movement
voltage-gated calcium channel activity
response to progesterone
sperm-egg recognition
cell-cell recognition
sperm motility
flagellated sperm motility
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
motile cilium
single fertilization
fertilization
response to ketone
calcium ion transmembrane transport
regulation of microtubule-based process
cell recognition
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
response to steroid hormone
regulation of ion transmembrane transport
spermatogenesis
inorganic cation transmembrane transport
regulation of transmembrane transport
male gamete generation
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
gamete generation
regulation of ion transport
multicellular organismal reproductive process
cation transport
sexual reproduction