CBFA2T3

Gene Information

Official Symbol: CBFA2T3
Official Name: CBFA2/RUNX1 partner transcriptional co-repressor 3
Aliases and Previous Symbols: N/A
Entrez ID: 863
UniProt: O75081
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	-2.09
Rapamycin 10μM R00 exp30	-1.97
Trametinib 10μM R02 exp83	-1.85
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.74
NFN1 0.1μM R01 exp49	1.73
BI-6727 0.0125μM R03 exp97	1.96
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.97
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2
Etoposide 1μM R00 exp19	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2730
Expression level (log2 read counts): 5.59

Expression Distribution

NHR2
TAFH
zf-MYND

regulation of aerobic respiration
negative regulation of glycolytic process
negative regulation of purine nucleotide metabolic process
negative regulation of nucleotide metabolic process
granulocyte differentiation
negative regulation of ATP metabolic process
regulation of cellular respiration
negative regulation of cellular carbohydrate metabolic process
negative regulation of carbohydrate metabolic process
regulation of glycolytic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of carbohydrate catabolic process
negative regulation of small molecule metabolic process
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
myeloid leukocyte differentiation
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of ATP metabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cellular carbohydrate metabolic process
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of generation of precursor metabolites and energy
regulation of proteasomal protein catabolic process
regulation of carbohydrate metabolic process
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
myeloid cell differentiation
transcription corepressor activity
regulation of cellular protein catabolic process
negative regulation of catabolic process
leukocyte differentiation
response to hypoxia
response to decreased oxygen levels
positive regulation of proteolysis
positive regulation of cellular catabolic process
response to oxygen levels
regulation of protein catabolic process