CCDC62

Entrez Summary: N/A
UniProt Summary: Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. {ECO:0000269|PubMed:19126643}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

organism emergence from protective structure
hatching
blastocyst hatching
cellular response to estradiol stimulus
estrogen receptor binding
nuclear receptor transcription coactivator activity
blastocyst development
response to estradiol
in utero embryonic development
cellular response to lipid
cellular response to organic cyclic compound
cellular response to hormone stimulus
chordate embryonic development
embryo development ending in birth or egg hatching
response to lipid
response to hormone
response to organic cyclic compound
embryo development
cellular response to oxygen-containing compound
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
response to endogenous stimulus
positive regulation of transcription, DNA-templated
response to oxygen-containing compound
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process