CCNH

Gene Information

Official Symbol: CCNH
Official Name: cyclin H
Aliases and Previous Symbols: N/A
Entrez ID: 902
UniProt: P51946
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:7533895}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Metformin 40μM R03 exp132	-2.23
Selumetinib 20μM R02 exp81	-2.03
GW501516 25μM R06 exp285	-1.87
Rotenone 2μM R00 exp33	-1.85
WYE-354 6μM R02 exp90	-1.85

Global Fraction of Cell Lines Where Essential: 537/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	19/28
blood	22/28
bone	22/25
breast	24/33
central nervous system	36/56
cervix	3/4
colorectal	11/17
esophagus	10/13
fibroblast	1/1
gastric	10/15
kidney	13/21
liver	14/20
lung	63/75
lymphocyte	9/14
ovary	20/26
pancreas	18/24
peripheral nervous system	13/16
plasma cell	13/15
prostate	1/1
skin	19/24
soft tissue	6/7
thyroid	2/2
upper aerodigestive	13/22
urinary tract	24/29
uterus	3/5

Essentiality in NALM6

Essentiality Rank: 1145
Expression level (log2 read counts): 5.52

Expression Distribution

Gene	Correlation
GTF2H4	0.423
GTF2H1	0.41

transcription factor TFIIK complex
cyclin-dependent protein kinase activating kinase holoenzyme complex
transcription factor TFIIH holo complex
RNA polymerase II CTD heptapeptide repeat kinase activity
transcription elongation from RNA polymerase I promoter
nucleotide-excision repair, preincision complex assembly
termination of RNA polymerase I transcription
7-methylguanosine mRNA capping
cyclin-dependent protein serine/threonine kinase regulator activity
7-methylguanosine RNA capping
RNA capping
transcription initiation from RNA polymerase I promoter
transcription by RNA polymerase I
DNA-dependent ATPase activity
DNA-templated transcription, termination
transcription-coupled nucleotide-excision repair
transcription elongation from RNA polymerase II promoter
DNA-templated transcription, elongation
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
nucleotide-excision repair
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
transcription initiation from RNA polymerase II promoter
protein stabilization
protein-DNA complex assembly
DNA-templated transcription, initiation
protein-DNA complex subunit organization
mitotic cell cycle phase transition
cell cycle phase transition
regulation of protein stability
mRNA processing
transcription by RNA polymerase II
DNA repair
regulation of protein serine/threonine kinase activity
mitotic cell cycle process
transcription, DNA-templated
nucleic acid-templated transcription