CCP110

Entrez Summary: N/A
UniProt Summary: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ciliary basal body organization
negative regulation of cilium assembly
centriole replication
centriole assembly
negative regulation of plasma membrane bounded cell projection assembly
positive regulation of cilium assembly
centrosome duplication
negative regulation of organelle assembly
positive regulation of organelle assembly
regulation of cilium assembly
centrosome cycle
regulation of cytokinesis
microtubule organizing center organization
ciliary basal body-plasma membrane docking
positive regulation of plasma membrane bounded cell projection assembly
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
centriole
regulation of cell division
organelle localization by membrane tethering
membrane docking
negative regulation of cell projection organization
regulation of G2/M transition of mitotic cell cycle
cilium
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of cell cycle G2/M phase transition
regulation of organelle assembly
mitotic cell cycle phase transition
cell cycle phase transition
protein deubiquitination
protein modification by small protein removal
cilium assembly
cilium organization
negative regulation of organelle organization
positive regulation of cell projection organization
regulation of mitotic cell cycle phase transition
plasma membrane bounded cell projection assembly
regulation of cell cycle phase transition
cell projection assembly