CD70

Entrez Summary: N/A
UniProt Summary: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
All-trans-Retinoic-Acid 40μM R07 exp334	-1.97
JQ1 0.01μM R03 exp130	-1.73

tumor necrosis factor receptor binding
B cell proliferation
T cell mediated immunity
lymphocyte proliferation
mononuclear cell proliferation
positive regulation of T cell proliferation
extrinsic apoptotic signaling pathway
leukocyte proliferation
protease binding
tumor necrosis factor-mediated signaling pathway
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
B cell activation
regulation of T cell proliferation
cytokine activity
positive regulation of T cell activation
regulation of lymphocyte proliferation
B cell mediated immunity
regulation of mononuclear cell proliferation
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
cellular response to tumor necrosis factor
positive regulation of cell-cell adhesion
response to tumor necrosis factor
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
apoptotic signaling pathway
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
signaling receptor binding
positive regulation of lymphocyte activation
lymphocyte activation
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
positive regulation of cell activation
regulation of lymphocyte activation
cell population proliferation
regulation of leukocyte activation