CDC42EP1

Gene Information

Official Symbol: CDC42EP1
Official Name: CDC42 effector protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 11135
UniProt: Q00587
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts. {ECO:0000269|PubMed:10430899}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12086
Expression level (log2 read counts): -2.17

Expression Distribution

Screen	Score
Hydroxyurea 15μM R06 exp289	1.86
Rifampicin 10μM R00 exp32	1.9

positive regulation of pseudopodium assembly
regulation of pseudopodium assembly
cadherin binding involved in cell-cell adhesion
GTP-Rho binding
endomembrane system
Rho protein signal transduction
positive regulation of actin filament polymerization
positive regulation of plasma membrane bounded cell projection assembly
cell-cell adherens junction
positive regulation of protein polymerization
regulation of cell shape
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
positive regulation of cytoskeleton organization
regulation of protein polymerization
Ras protein signal transduction
positive regulation of protein complex assembly
regulation of actin filament organization
small GTPase mediated signal transduction
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
cytoskeleton
regulation of cellular component size
positive regulation of cell projection organization
regulation of actin filament-based process
focal adhesion
regulation of protein complex assembly
regulation of cell morphogenesis
cell-cell adhesion
regulation of anatomical structure size
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
positive regulation of organelle organization
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
cell adhesion